Responsible Use of Opioids

According to the Centers for Disease Control and Prevention (CDC) Guideline for Prescribing Opioids for Chronic Pain, opioids are not the first-line therapy for chronic pain outside of active cancer treatment, palliative care, and end-of-life care.² The CDC recommends using nonopioid therapies to the extent possible, including non-drug treatments (e.g., exercise, cognitive behavioral therapy, and interdisciplinary rehabilitation).³ Read more information available on the CDC website about nonopioid therapies for pain management.

Prescription opioids should only be considered when alternative treatment options are inadequate and expected benefits outweigh potential risks to the patient. The CDC recommends that if opioid medications are prescribed, they should be given at the lowest effective dose and for the shortest adequate duration.² If a healthcare professional prescribes an opioid to help with your pain, ask questions and be sure you fully understand a given course of treatment, including when and how to properly stop taking the medication.⁴ Never increase the dosage or frequency of taking your medications or add other medications on your own. It’s important to discuss the risks of the opioid medication you are prescribed and make sure to tell your prescriber about any past substance use issues with drugs or alcohol, about you and your family’s history of addiction or mental illness, as well as about any other medications you are taking.

To help reduce the risk of dangerous drug interactions, be sure to tell your doctors and pharmacists about all the medications you are currently taking.⁴ Taking opioids in combination with certain prescription or over-the-counter medicines or other substances—including alcohol—can result in serious harm or even death. Don’t take an opioid pain medicine unless it has been prescribed for you by a healthcare practitioner, and be sure to follow their instructions—to the letter.

Additional information about the risks and side effects of opioid use can be found on the CDC website.

Medication Guides are handouts that come with many prescription medications. While many pharmacies provide printed information when a medication is picked up, Medication Guides are different because the FDA approves the content of every Medication Guide, and your pharmacist is required to give you one each time you pick up your opioid prescription. Medication Guides for opioids contain important information for patients and caregivers about serious and common risks, including misuse, abuse, addiction, overdose, and death. Medication Guides also include information about safe storage and safe disposal of unused medication.

Look for the words “Medication Guide” at the top of the page to ensure you are reading the correct document and ask your pharmacist any questions about your medication. Drug products that have Medication Guides can also be found on the FDA’s website.

Never, ever share your medication with another person. Remember, medication that your doctor has determined is OK for you when taken as directed may pose serious or life-threatening risks for someone else.⁴ Also, sharing prescription medications is against the law.

Never leave opioids where family, friends, children, or visitors may have access to them, including in your medicine cabinet. Once an opioid medication is no longer required, be sure to dispose of it properly by bringing it to a community collection site or drug take-back program, or flushing it down the toilet, if a drug take-back option is not readily available.⁵ You can also ask your pharmacist about pre-paid drug mail-back envelopes.

The Drug Enforcement Administration (DEA) offers a helpful locator to find your nearest collection site.

With opioids, disposing of unused or unneeded medications is particularly important because more than 40 percent of people who report that they have misused prescription opioids say they have gotten them from friends or relatives—in other words, the medicine they misused was not prescribed for them.⁶ Unused medications can also become a household danger when consumed accidentally, especially by small children, resulting in emergency room visits, hospitalization and even death.⁷

Additional information on medication disposal is available on the FDA’s website and the Opioid Analgesics REMS website.

Addiction is a chronic, relapsing disease and, as such, needs treatment. If you or someone you know is struggling with opioid addiction, seek help. The Substance Abuse and Mental Health Services Administration’s (SAMHSA) confidential and anonymous Behavioral Health Treatment Services Locator can be accessed here, and the free and confidential National Helpline can be reached through 1-800-662-HELP (4357) and 1-800-487-4889 (TTY).

Learn more about the risks of opioids on the CDC’s website.